Transglutaminase 2 Deficiency Decreases Plaque Fibrosis and Increases Plaque Inflammation in Apolipoprotein-E-Deficient Mice | Zendy

Jozef L. Van Herck | Zendy; D. Schrijvers | Zendy; Guido R.Y. De Meyer | Zendy; Wim Martinet | Zendy; Cor E. Van Hove | Zendy; Hidde Bult | Zendy; Christiaan Vrints | Zendy; Arnold G. Herman | Zendy

Open Access

Transglutaminase 2 Deficiency Decreases Plaque Fibrosis and Increases Plaque Inflammation in Apolipoprotein-E-Deficient Mice

Author(s) -

Jozef L. Van Herck,

D. Schrijvers,

Guido R.Y. De Meyer,

Wim Martinet,

Cor E. Van Hove,

Hidde Bult,

Christiaan Vrints,

Arnold G. Herman

Publication year - 2009

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000255966

Subject(s) - apolipoprotein e , sirius red , tissue transglutaminase , inflammation , endocrinology , medicine , apolipoprotein b , staining , extracellular matrix , biology , fibrosis , chemistry , pathology , cholesterol , biochemistry , enzyme , disease

Transglutaminase 2 (TG2) is important for the deposition and stability of the extracellular matrix via effects on cross-linking of matrix proteins and transforming growth factor beta (TGFbeta) activity. The purpose of this study was to investigate the effect of TG2 deficiency on the composi- tion of atherosclerotic plaques.

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