Differences in Lesion Severity and Cellular Composition between in vivo Assessed Upstream and Downstream Sides of Human Symptomatic Carotid Atherosclerotic Plaques | Zendy

Björn Fagerberg | Zendy; M. Ryndel | Zendy; Josefin Kjelldahl | Zendy; Levent M. Akyürek | Zendy; Lars Rosengren | Zendy; Lars Karlström | Zendy; Göran Bergström | Zendy; Fredrik J. Olson | Zendy

Open Access

Differences in Lesion Severity and Cellular Composition between in vivo Assessed Upstream and Downstream Sides of Human Symptomatic Carotid Atherosclerotic Plaques

Author(s) -

Björn Fagerberg,

M. Ryndel,

Josefin Kjelldahl,

Levent M. Akyürek,

Lars Rosengren,

Lars Karlström,

Göran Bergström,

Fredrik J. Olson

Publication year - 2009

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000255965

Subject(s) - stenosis , fibrous cap , carotid endarterectomy , medicine , pathology , lesion , magnetic resonance imaging , blood flow , upstream and downstream (dna) , in vivo , histopathology , radiology , upstream (networking) , biology , microbiology and biotechnology , computer network , computer science

The heterogeneous structure of carotid atherosclerotic plaques may be better understood if it is related to blood flow variations, influencing gene expression and cellular functions. Upstream of the maximum stenosis there is laminar blood flow and high shear stress, downstream there is turbulence and low shear stress. We studied if these variations were associated with differences in plaque morphology and composition between sites located up- and downstream of the maximum stenosis in symptomatic carotid plaques.

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