Open AccessIbuprofen Modulates NF-ĸB Activity but Not IL-8 Production in Cystic Fibrosis Respiratory Epithelial Cells
Author(s) -
Nurlan Dauletbaev,
Joyce Ching Mei Lam,
Daniel Eklove,
Michèle M. Iskandar,
Larry C. Lands
Publication year - 2009
Publication title -
respiration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.264
H-Index - 81
eISSN - 1423-0356
pISSN - 0025-7931
DOI - 10.1159/000255342
Subject(s) - ibuprofen , tumor necrosis factor alpha , cystic fibrosis , medicine , respiratory epithelium , dexamethasone , endocrinology , nfkb1 , nf κb , interleukin 8 , inflammation , microbiology and biotechnology , respiratory system , biology , transcription factor , pharmacology , biochemistry , gene
High-dose ibuprofen is clinically effective in cystic fibrosis (CF); however, its molecular mechanisms are poorly understood.
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