Fibrinogen That Appears in Bowman’s Space of Proteinuric Kidneys in vivo Activates Podocyte Toll-Like Receptors 2 and 4 in vitro | Zendy

Masaru Motojima | Zendy; Taiji Matsusaka | Zendy; Valentina Kon | Zendy; Iekuni Ichikawa | Zendy

Open Access

Fibrinogen That Appears in Bowman’s Space of Proteinuric Kidneys in vivo Activates Podocyte Toll-Like Receptors 2 and 4 in vitro

Author(s) -

Masaru Motojima,

Taiji Matsusaka,

Valentina Kon,

Iekuni Ichikawa

Publication year - 2009

Publication title -

nephron experimental nephrology

Language(s) - English

Resource type - Journals

ISSN - 1660-2129

DOI - 10.1159/000254390

Subject(s) - podocyte , gene knockdown , downregulation and upregulation , receptor , fibrinogen , tlr2 , endocrinology , medicine , chemistry , toll like receptor , tlr4 , microbiology and biotechnology , kidney , biology , proteinuria , innate immune system , apoptosis , biochemistry , gene

Composition of nonselective proteinuria includes several endogenous ligands of Toll-like receptors (TLRs) not normally present in Bowman's space, thus raising the possibility that TLRs are involved in proteinuria-mediated podocyte injury.

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