Fixed Drug Eruption Induced by Griseofulvin

O. Boudghene-Stambouli. A. Mérad-Boudia, Service de Dermato-Vénéréologie, Centre Hospitalo-Universitaire, 15, rue Bellevue, 13000 Tlemcen (Algeria) Sir. A male policeman had been treated, in February 1986, for a tinea cruris from which a Trichυphytυn rubrum had been isolated. He received 1 g of griseofulvin daily for a month combined with topical miconazole. He came back 5 months later because the tinea cruris had reappeared. The same treatment was recommended. Forty-five days later he presented with brown pigmented macules of different sizes, round or oval on the left leg. the back and the armpits. The examination revealed that the lesions represented a typical fixed drug eruption. The patient claimed that ‘they reappeared a few hours after intake in the same places as before’, i.e. during the first course of griseofulvin. We were not aware of this fact. The evolution toward pigmentation was very quick after the interruption of the treatment. Letters to the Editor 93