A Case of Bullous Systemic Lupus erythematosus | Zendy

Shigeho Shirahama | Zendy; Hiroaki Yagi | Zendy; Fukumi Furukawa | Zendy; Masaharu Takigawa | Zendy

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A Case of Bullous Systemic Lupus erythematosus

Author(s) -

Shigeho Shirahama,

Hiroaki Yagi,

Fukumi Furukawa,

Masaharu Takigawa

Publication year - 1994

Publication title -

dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.224

H-Index - 92

eISSN - 1421-9832

pISSN - 1018-8665

DOI - 10.1159/000246941

Subject(s) - blisters , dermoepidermal junction , dapsone , dermatology , medicine , direct fluorescent antibody , lupus erythematosus , skin biopsy , biopsy , trunk , systemic disease , connective tissue disease , pathology , immunopathology , autoimmune disease , antibody , immunology , dermis , disease , biology , ecology

We report a case of bullous systemic lupus erythematosus (SLE). The patient suddenly presented with a widespread blistering eruption on the trunk and neck during the course of treatment of SLE. A skin biopsy specimen showed subepidermal blisters, and direct immunofluorescence (IF) revealed deposition of IgA, IgG and IgM at the dermoepidermal junction. Indirect IF showed linear IgG deposition along the base of 1 M NaCl-split skin. Rapid resolution of the blisters occurred following treatment with dapsone 50 mg daily.

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