Open AccessPathophysiology of Osteoarthritis: Evidence against the Viscoelastic Theory
Author(s) -
Sharon Dunn,
Oleg V. Kolomytkin,
Andrew A. Marino
Publication year - 2009
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000245898
Subject(s) - osteoarthritis , synovial fluid , medicine , pathophysiology , hyaluronic acid , gastroenterology , pathology , endocrinology , anatomy , alternative medicine
Whether changes in the hyaluronan moiety of synovial fluid are associated with osteoarthritis (OA) is unresolved experimentally, notwithstanding frequent statements in the literature that the disease leads to degraded hyaluronan. We evaluated this hypothesis by comparing the molecular weight and concentration of hyaluronan in synovial fluid from patients with and without OA.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom