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We investigated whether the phosphorylated Fas-associated death domain protein (FADD) at serine 194 regulated human telomerase reverse transcriptase (hTERT) expression, telomerase activity and cancer progression using prostate cancer cell lines and radical prostatectomy samples taken from patients receiving neoadjuvant hormonal therapy (NHT).

pathobiology

Phosphorylation Status of Fas-Associated Death Domain-Containing Protein Regulates Telomerase Activity and Strongly Correlates with Prostate Cancer Outcomes