Role of Seminiferous Tubular Development in Determining the FSH versus LH Responsiveness to GnRH in Early Sexual Maturation | Zendy

Nelly Pitteloud | Zendy; Apisadaporn Thambundit | Zendy; Andrew Dwyer | Zendy; John Falardeau | Zendy; Lacey Plummer | Zendy; Lisa M. Caronia | Zendy; Frances J. Hayes | Zendy; Hang Lee | Zendy; Paul A. Boepple | Zendy; William F. Crowley | Zendy

Open Access

Role of Seminiferous Tubular Development in Determining the FSH versus LH Responsiveness to GnRH in Early Sexual Maturation

Author(s) -

Nelly Pitteloud,

Apisadaporn Thambundit,

Andrew Dwyer,

John Falardeau,

Lacey Plummer,

Lisa M. Caronia,

Frances J. Hayes,

Hang Lee,

Paul A. Boepple,

William F. Crowley

Publication year - 2009

Publication title -

neuroendocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.493

H-Index - 101

eISSN - 1423-0194

pISSN - 0028-3835

DOI - 10.1159/000245383

Subject(s) - medicine , endocrinology , hypogonadotropic hypogonadism , gonadotropin releasing hormone , testosterone (patch) , gonadotropin , blood sampling , sexual maturity , delayed puberty , hormone , luteinizing hormone , biology

The onset of sexual maturation at puberty is a unique developmental period from a neuroendocrine perspective in that it is characterized by enhanced FSH secretion and FSH responsiveness to exogenous GnRH (vs. LH) from the gonadotrope, yet the mechanism of these dynamics remains unclear. This study aimed to elucidate this phenomenon using a human disease model of GnRH deficiency (idiopathic hypogonadotropic hypogonadism, IHH) in which GnRH input can be experimentally controlled.

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