The Role of Hepcidin in Iron Metabolism | Zendy

Elizabeta Nemeth | Zendy; Tomas Ganz | Zendy

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The Role of Hepcidin in Iron Metabolism

Author(s) -

Elizabeta Nemeth,

Tomas Ganz

Publication year - 2009

Publication title -

acta haematologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 56

eISSN - 1421-9662

pISSN - 0001-5792

DOI - 10.1159/000243791

Subject(s) - hepcidin , hemochromatosis , hereditary hemochromatosis , anemia of chronic disease , anemia , iron homeostasis , medicine , inflammation , iron deficiency , disease , immunology , iron deficiency anemia , endocrinology , metabolism

Hepcidin is the central regulator of systemic iron homeostasis. Dysregulation of hepcidin production results in a variety of iron disorders. Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin excess is associated with anemia of inflammation, chronic kidney disease and iron-refractory iron deficiency anemia. Diagnostic and therapeutic applications of this new knowledge are beginning to emerge. Dr. Ernest Beutler played a significant role in advancing our understanding of the function of hepcidin. This review is dedicated to his memory.

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