Iloprost Improves Gas Exchange and Exercise Tolerance in Patients with Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease | Zendy

Tarek A. Dernaika | Zendy; Mikel Beavin | Zendy; Gary T. Kinasewitz | Zendy

Open Access

Iloprost Improves Gas Exchange and Exercise Tolerance in Patients with Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease

Author(s) -

Tarek A. Dernaika,

Mikel Beavin,

Gary T. Kinasewitz

Publication year - 2009

Publication title -

respiration

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.264

H-Index - 81

eISSN - 1423-0356

pISSN - 0025-7931

DOI - 10.1159/000242498

Subject(s) - medicine , iloprost , copd , pulmonary hypertension , cardiology , respiratory disease , hypoxic pulmonary vasoconstriction , perfusion , lung , anesthesia , prostacyclin

Nonselective systemic vasodilators worsen ventilation perfusion (V/Q) matching and gas exchange in patients with chronic obstructive pulmonary disease (COPD). Inhaled iloprost has the potential to act preferentially in ventilated regions of the lung, thereby reducing pulmonary hypertension (PH) while alveolar ventilation is still maintained.

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