Effect of Pioglitazone on Survival and Renal Function in a Mouse Model of Polycystic Kidney Disease | Zendy

Kalani L. Raphael | Zendy; Kevin A. Strait | Zendy; Peter K. Stricklett | Zendy; B. Baird | Zendy; Klaus Piontek | Zendy; Gregory G. Germino | Zendy; Donald E. Kohan | Zendy

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Effect of Pioglitazone on Survival and Renal Function in a Mouse Model of Polycystic Kidney Disease

Author(s) -

Kalani L. Raphael,

Kevin A. Strait,

Peter K. Stricklett,

B. Baird,

Klaus Piontek,

Gregory G. Germino,

Donald E. Kohan

Publication year - 2009

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000242432

Subject(s) - pioglitazone , polycystic kidney disease , medicine , pkd1 , kidney , renal function , endocrinology , cyst , kidney disease , nephrology , diabetes mellitus , pathology , type 2 diabetes

Cystic epithelia in polycystic kidney disease display features similar to malignant cells. Thiazolidinediones have been shown to have anti-neoplastic properties, therefore we tested the hypothesis that pioglitazone reduces cyst formation, improves renal function, and prolongs survival in a mouse model of polycystic kidney disease.

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