Blocking the Glucocorticoid Receptor with RU-486 Does Not Prevent Glucocorticoid Control of Autoimmune Mouse Hearing Loss | Zendy

Dennis R. Trune | Zendy; J. Beth Kempton | Zendy

Open Access

Blocking the Glucocorticoid Receptor with RU-486 Does Not Prevent Glucocorticoid Control of Autoimmune Mouse Hearing Loss

Author(s) -

Dennis R. Trune,

J. Beth Kempton

Publication year - 2009

Publication title -

audiology and neurotology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.106

H-Index - 78

eISSN - 1421-9700

pISSN - 1420-3030

DOI - 10.1159/000241899

Subject(s) - glucocorticoid , blocking (statistics) , glucocorticoid receptor , hearing loss , receptor , endocrinology , medicine , audiology , computer science , computer network

Glucocorticoids effectively manage autoimmune hearing loss, although the cochlear mechanisms involved are unknown. Previous studies of steroid-responsive hearing loss in autoimmune (lupus) mice showed glucocorticoids and mineralocorticoids were equally effective, suggesting the ion homeostasis functions of glucocorticoids may be as relevant as immunosuppression for control of autoimmune-induced inner ear disease. Therefore, to better characterize the role of the glucocorticoid receptor in autoimmune hearing loss therapy, its function was blocked with the antagonist RU-486 (mifepristone) during glucocorticoid (prednisolone) treatments.

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