Selenoprotein P, Rather than Glutathione Peroxidase, as a Potential Marker of Septic Shock and Related Syndromes | Zendy

Xavier Forceville | Zendy; Volker Mostert | Zendy; A. Pierantoni | Zendy; Dominique Vitoux | Zendy; Philippe Le Toumelin | Zendy; Elisabeth Plouvier | Zendy; Monique Dehoux | Zendy; F. Thuillier | Zendy; Alain Combes | Zendy

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Selenoprotein P, Rather than Glutathione Peroxidase, as a Potential Marker of Septic Shock and Related Syndromes

Author(s) -

Xavier Forceville,

Volker Mostert,

A. Pierantoni,

Dominique Vitoux,

Philippe Le Toumelin,

Elisabeth Plouvier,

Monique Dehoux,

F. Thuillier,

Alain Combes

Publication year - 2009

Publication title -

european surgical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.658

H-Index - 46

eISSN - 1421-9921

pISSN - 0014-312X

DOI - 10.1159/000239763

Subject(s) - septic shock , selenoprotein p , medicine , sepsis , glutathione peroxidase , shock (circulatory) , selenoprotein , systemic inflammatory response syndrome , oxidative stress , multiple organ dysfunction syndrome , endocrinology , gastroenterology , superoxide dismutase

Oxidative stress is involved in sepsis-related endothelium dysfunction. Selenoprotein-P (Sel-P), the main plasma selenoprotein, may have high antioxidant potential, and binds to endothelium. We hypothesize that, in septic shock, and similar syndromes such as systemic inflammatory response syndrome (SIRS), Sel-P binds massively to endothelium, causing a drop in Sel-P plasma concentration.

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