Inhibition of Pulmonary Eosinophilia and Hyperreactivity by Antibodies to lnterleukin-5 | Zendy

Robert W. Egan | Zendy; Diljeet Athwahl | Zendy; ChuanChu Chou | Zendy; Spencer Emtage | Zendy; Chung-Her Jehn | Zendy; Ted T. Kung | Zendy; Peter Mauser | Zendy; Nicholas Murgolo | Zendy; Mark Bodmer | Zendy

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Inhibition of Pulmonary Eosinophilia and Hyperreactivity by Antibodies to lnterleukin-5

Author(s) -

Robert W. Egan,

Diljeet Athwahl,

ChuanChu Chou,

Spencer Emtage,

Chung-Her Jehn,

Ted T. Kung,

Peter Mauser,

Nicholas Murgolo,

Mark Bodmer

Publication year - 1995

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000237014

Subject(s) - eosinophilia , immunology , pulmonary eosinophilia , antibody , interleukin 5 , medicine , immunoglobulin e , inflammation , asthma , allergic inflammation , bronchial hyperreactivity , allergy , interleukin , respiratory disease , eosinophil , lung , cytokine

Eosinophils infiltrate into the lungs during asthma and may cause the damage associated with pulmonary inflammation. In allergic animal models, antibodies to interleukin (IL)-5 inhibit pulmonary eosinophilia, tissue damage and hyperreactivity. Sch 55700, a humanized antibody against human IL-5, inhibits eosinophilia in these models with an extended biological duration. On the basis of this dosing regimen and the humanized nature of Sch 55700, it is anticipated that the host response leading to tolerance would be minimized.

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