Inhaled Corticosteroid Treatment and Extracellular Matrix in the Airways in Asthma | Zendy

Lauri A. Laitinen | Zendy; Annika Laitinen | Zendy

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Inhaled Corticosteroid Treatment and Extracellular Matrix in the Airways in Asthma

Author(s) -

Lauri A. Laitinen,

Annika Laitinen

Publication year - 1995

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000236981

Subject(s) - basement membrane , asthma , airway , immunology , inflammation , medicine , extracellular matrix , epithelium , respiratory epithelium , respiratory disease , corticosteroid , mucous membrane , pathology , lung , biology , microbiology and biotechnology , anesthesia

Even mild asthmatics with a short duration of the disease show at the morphological level a picture of chronic inflammation with airway epithelial changes and influx of inflammatory cells into the airway mucosa. Several studies have shown that inhaled corticosteroid treatment can ameliorate this inflammation. In addition, even a morphologically normal epithelial structure may be restored. However, factors which may lead to more chronic disease have remained obscure. Recent studies are now focusing on the reversibility of collagen deposition in the airway epithelial basement membrane. Airway epithelial and stromal interactions may be important when a change at this level occurs.

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