Role of Heat Shock Protein 65/60 in the Pathogenesis of Atherosclerosis | Zendy

Georg Wick | Zendy; Roman Kleindienst | Zendy; Georg Schett | Zendy; Albert Amberger | Zendy; Qingbo Xu | Zendy

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Role of Heat Shock Protein 65/60 in the Pathogenesis of Atherosclerosis

Author(s) -

Georg Wick,

Roman Kleindienst,

Georg Schett,

Albert Amberger,

Qingbo Xu

Publication year - 1995

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000236952

Subject(s) - pathogenesis , heat shock protein , immunology , infiltration (hvac) , shock (circulatory) , antibody , medicine , biology , gene , biochemistry , physics , thermodynamics

Investigations in rabbits and humans have provided experimental evidence that autoimmune reactions play a major role in the initial stages of the development of atherosclerosis. These involve the infiltration of the arterial intima with T cells reacting with heat shock protein (hsp) 65/60 and the occurrence of anti-hsp 65/60 antibodies. This early immunologically mediated stage of atherosclerosis is still reversible but if additional risk factors, such as high cholesterol levels, come into effect, severe mostly irreversible lesions develop.

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