Expression of the CD40 Ligand in T Lymphocytes and Induction of IgE Isotype Switching | Zendy

Ramsay Fuleihan | Zendy; Deborah Ahern | Zendy; Raif S. Geha | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Expression of the CD40 Ligand in T Lymphocytes and Induction of IgE Isotype Switching

Author(s) -

Ramsay Fuleihan,

Deborah Ahern,

Raif S. Geha

Publication year - 1995

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000236925

Subject(s) - isotype , immunoglobulin class switching , immunoglobulin e , cd40 , immunology , interleukin 4 , biology , t cell , antibody , microbiology and biotechnology , b cell , chemistry , cytokine , cytotoxic t cell , monoclonal antibody , immune system , in vitro , biochemistry

CD40 ligand (CD40L) delivers a contact-dependent signal to B cells which, in the presence of interleukin (IL)-4, drives immunoglobulin isotype switching to IgE. CD40L expression in T cells is transient, requires activation of protein kinase C and a rise in intracellular calcium concentration ([Ca2+]i), and is inhibited by cyclosporin A (CsA). CsA also inhibited T-cell-dependent IL-4-driven IgE synthesis. We have found that expression of CD40L is developmentally regulated. Expression of CD40L was restricted to mature single-positive thymocytes which, in the presence of IL-4, were capable of inducing B cells to undergo IgE isotype switching. CD40L expression was severely decreased in cord blood lymphocytes and was associated with a severely decreased ability to undergo T-cell-dependent IgE isotype switching.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research