CNGA2 Contributes to ATP-Induced Noncapacitative Ca2+ Influx in Vascular Endothelial Cells | Zendy

Hiu Yee Kwan | Zendy; Kwong-Tai Cheng | Zendy; Yan Ma | Zendy; Yü Huang | Zendy; Nelson L.S. Tang | Zendy; Shan Yu | Zendy; Xiaoqiang Yao | Zendy

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CNGA2 Contributes to ATP-Induced Noncapacitative Ca<sup>2+</sup> Influx in Vascular Endothelial Cells

Author(s) -

Hiu Yee Kwan,

Kwong-Tai Cheng,

Yan Ma,

Yü Huang,

Nelson L.S. Tang,

Shan Yu,

Xiaoqiang Yao

Publication year - 2009

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000235969

Subject(s) - chemistry , endothelium , endothelial stem cell , microbiology and biotechnology , medicine , endocrinology , biochemistry , biology , in vitro

ATP can activate several Ca(2+) influx channels in vascular endothelial cells. For example, it stimulates TRPC channels via capacitative and noncapacitative Ca(2+) entry (CCE and non-CCE, respectively) mechanisms; it also directly acts on P2X purinoceptors, resulting in Ca(2+) influx. In the present study, we tested the hypothesis that cyclic nucleotide-gated (CNG) channels also contribute to ATP-induced non-CCE.

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