Improving Enrichment of Circulating Fetal DNA for Genetic Testing: Size Fractionation Followed by Whole Gene Amplification | Zendy

Carolina J. Jorgez | Zendy; Farideh Z. Bischoff | Zendy

Open Access

Improving Enrichment of Circulating Fetal DNA for Genetic Testing: Size Fractionation Followed by Whole Gene Amplification

Author(s) -

Carolina J. Jorgez,

Farideh Z. Bischoff

Publication year - 2009

Publication title -

fetal diagnosis and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 60

eISSN - 1421-9964

pISSN - 1015-3837

DOI - 10.1159/000235877

Subject(s) - dna , microbiology and biotechnology , agarose gel electrophoresis , fetus , biology , dna extraction , globin , cell free fetal dna , polymerase chain reaction , genomic dna , andrology , amplicon , pregnancy associated plasma protein a , gene , prenatal diagnosis , medicine , genetics , pregnancy , first trimester

Among the pitfalls of using cell-free fetal DNA in plasma for prenatal diagnosis is quality of the recovered DNA fragments and concomitant presence of maternal DNA (>95%). Our objective is to provide alternative methods for achieving enrichment and high-quality fetal DNA from plasma.

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