Increased Renal Proximal Convoluted Tubule Transport Contributes to Hypertension in Cyp4a14 Knockout Mice | Zendy

Raymond Quigley | Zendy; Sumana Chakravarty | Zendy; Xueying Zhao | Zendy; John D. Imig | Zendy; Jorge H. Capdevila | Zendy

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Increased Renal Proximal Convoluted Tubule Transport Contributes to Hypertension in Cyp4a14 Knockout Mice

Author(s) -

Raymond Quigley,

Sumana Chakravarty,

Xueying Zhao,

John D. Imig,

Jorge H. Capdevila

Publication year - 2009

Publication title -

nephron physiology

Language(s) - English

Resource type - Journals

ISSN - 1660-2137

DOI - 10.1159/000235774

Subject(s) - knockout mouse , endocrinology , reabsorption , medicine , distal convoluted tubule , kidney , sodium–hydrogen antiporter , convoluted tubule , chemistry , renal sodium reabsorption , wild type , angiotensin ii , cotransporter , renin–angiotensin system , gene knockout , brush border , sodium , biology , receptor , blood pressure , biochemistry , organic chemistry , gene , mutant , vesicle , membrane

Disrupting the enzyme Cyp4a14 in mice leads to hypertension, which is more severe in the male mice and appears to be due to androgen excess. Because the Cyp4a14 enzyme is located in the proximal tubule of the kidney, we hypothesized that there could be dysregulation of transport in this segment that could contribute to the hypertension.

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