Intracellular Extraocular Muscle Light- and Heavy-Chain Deposition Disease Contributing to Compressive Optic Neuropathy in a Patient with Preexisting Graves’ Orbitopathy

Light- and heavy-chain deposition disease (LHCDD) is a rare form of nonamyloidal monoclonal immunoglobulin deposition disease (MIDD) in which light- and heavy-chain immunoglobulin fragments accumulate systemically, typically leading to end organ dysfunction. Herein we describe the case of a 64-year-old female with a history of Graves' orbitopathy and multiple myeloma who presented with bilateral asymmetric compressive optic neuropathies.