Induction of FcεRII/CD23 on Human T Cells by Excretory and Secretory Antigen of Dirofilaria immitis | Zendy

Kunio Yamaoka | Zendy; Setsuko Tsukidate | Zendy; Megumu Higaki | Zendy; Nobuyuki Miyasaka | Zendy; Koichirô Fujita | Zendy

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Induction of FcεRII/CD23 on Human T Cells by Excretory and Secretory Antigen of <i>Dirofilaria immitis</i>

Author(s) -

Kunio Yamaoka,

Setsuko Tsukidate,

Megumu Higaki,

Nobuyuki Miyasaka,

Koichirô Fujita

Publication year - 1991

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000235460

Subject(s) - cd23 , immunology , biology , antigen , flow cytometry , antibody , immunoglobulin e , excretory system , dirofilaria immitis , microbiology and biotechnology , endocrinology , helminths

We investigated the capacity of excretory and secretory antigen (ES) derived from living filarial worms in the induction of CD23 expression on human peripheral blood T cells by using flow cytometry. ES (10 micrograms/ml) significantly induced the expression of CD23 on human T cells. Moreover, increased CD23 expression was completely abolished by preincubation with specific antibody to ES. The results suggest that ES might play a certain role in IgE antibody production by induction of CD23 expression on T cells.

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