Definition of Platelet-Derived Histamine-Releasing Factor and Histaminergic Receptors Modulating Platelet Aggregation | Zendy

P. F. Mannaioni | Zendy; Alessandra Pistelli | Zendy; Francesco Gambassi | Zendy; M. G. Di Bello | Zendy; S. Raspanti | Zendy; Emanuela Masini | Zendy

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Definition of Platelet-Derived Histamine-Releasing Factor and Histaminergic Receptors Modulating Platelet Aggregation

Author(s) -

P. F. Mannaioni,

Alessandra Pistelli,

Francesco Gambassi,

M. G. Di Bello,

S. Raspanti,

Emanuela Masini

Publication year - 1991

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000235391

Subject(s) - mepyramine , histamine , platelet , histaminergic , chemistry , mast cell , thrombin , histamine h1 receptor , histamine h2 receptor , receptor , pharmacology , endogeny , platelet activating factor , endocrinology , medicine , immunology , biochemistry , biology , antagonist

Endogenous and exogenous free radical scavengers significantly decrease mast cell histamine release induced by coincubation with resting, activated platelets or with platelet-derived supernatant. Histamine and pyridylethylamine dose-dependently enhance platelet aggregation; the effect is potentiated by ranitidine and blocked by mepyramine. Histamine increases also cytosolic calcium concentration in platelets stimulated with thrombin, and binding sites for [3H]-mepyramine are present on platelet membranes.

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