Disodium Cromoglycate Inhibits Immunoglobulin Production in vitro without Affecting Cell Growth in Human B Cell Lines | Zendy

Hajime Kimata | Zendy; Akira Yoshida | Zendy; Chihiro Ishioka | Zendy; Harukí Mikawa | Zendy

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Disodium Cromoglycate Inhibits Immunoglobulin Production in vitro without Affecting Cell Growth in Human B Cell Lines

Author(s) -

Hajime Kimata,

Akira Yoshida,

Chihiro Ishioka,

Harukí Mikawa

Publication year - 1990

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000235314

Subject(s) - disodium cromoglycate , in vitro , immunoglobulin e , antibody , immunology , cell culture , cell , b cell , chemistry , thymidine , biology , microbiology and biotechnology , asthma , biochemistry , genetics

The effect of disodium cromoglycate (DSCG) on human B cell lines (IM-9, GM-1056, and AF-10) was studied. DSCG inhibited immunoglobulin production by these B cell lines without affecting thymidine uptake or cell number. Thus, in addition to its antiallergic function, DSCG may also act as a B cell-modulating reagent in vitro.

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