Epigenetic Profiling in Schizophrenia and Major Mental Disorders | Zendy

Kazuya Iwamoto | Zendy; Tadafumi Kato | Zendy

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Epigenetic Profiling in Schizophrenia and Major Mental Disorders

Author(s) -

Kazuya Iwamoto,

Tadafumi Kato

Publication year - 2009

Publication title -

neuropsychobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.71

H-Index - 83

eISSN - 1423-0224

pISSN - 0302-282X

DOI - 10.1159/000234811

Subject(s) - epigenetics , dna methylation , histone , schizophrenia (object oriented programming) , epigenomics , methylation , biology , genetics , psychiatry , medicine , dna , gene , gene expression

Epigenetic alterations such as DNA methylation and histone modifications are important in the etiology or pathophysiology of mental disorders. Here, we review recent studies on the relationship between DNA methylation and major mental disorders. We will focus on the role of DNA methylation in postmitotic neurons, intra- and interindividual variations in DNA methylation, the possible involvement of methionine metabolism pathways, and candidate and genome-wide DNA methylation as they relate to mental disorders.

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