Prostaglandin H Synthetase Activates Xenobiotics into Free Radicals: Histamine Release and Biochemical Characteristics | Zendy

Emanuela Masini | Zendy; E. Giannella | Zendy; B. Palmerani | Zendy; Alessandra Pistelli | Zendy; Francesco Gambassi | Zendy; Pier Francesco Mannaioni | Zendy

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Prostaglandin H Synthetase Activates Xenobiotics into Free Radicals: Histamine Release and Biochemical Characteristics

Author(s) -

Emanuela Masini,

E. Giannella,

B. Palmerani,

Alessandra Pistelli,

Francesco Gambassi,

Pier Francesco Mannaioni

Publication year - 1989

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000234766

Subject(s) - histamine , phosphatidylinositol , second messenger system , endogeny , chemistry , calcium , cytosol , biochemistry , radical , endocrinology , receptor , medicine , biology , signal transduction , enzyme , organic chemistry

In isolated rat serosal mast cells, studies with the fluorescent Ca2+ indicator, quin 2, and with [3H]-myoinositol to label endogenous polyphosphoinositides have established that an increase in cytosol Ca2+ levels was obligatory for histamine release by free radicals. No substantial breakdown of phosphatidylinositol and related polyphosphoinositides was associated with generation of the Ca2+ signal and histamine release, suggesting that the release of histamine by free radicals entails different pathways than the calcium-mobilizing receptors linked to polyphosphoinositides as second messengers.

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