Calcium Channels and Histamine Release from Mast Cells | Zendy

G.B. West | Zendy

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Calcium Channels and Histamine Release from Mast Cells

Author(s) -

G.B. West

Publication year - 1987

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000234405

Subject(s) - histamine , calcium , dextran , chemistry , ionophore , antagonist , calcium in biology , pharmacology , mast cell , endocrinology , biochemistry , biology , immunology , receptor , organic chemistry

Using isolated peritoneal mast cells from two types of genetically different rats, histamine release induced by allergic stimuli was inhibited, in all cases except one, by significantly lower concentrations of an intracellular calcium antagonist than those required to inhibit release induced by a calcium ionophore. The exception related to inhibition of histamine release induced by clinical dextran in NR rats (which are relatively less sensitive to dextran than are control rats) as the concentrations required were of a similar order as those needed to inhibit release by ionophores. The data further support the suggestion that there are different calcium channels involved in the different release processes.

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