The Presence in Blood of Both Glycosaminoglycan and Mucosal Mast Cell Protease following Systemic Anaphylaxis in the Rat | Zendy

Stephen J. King | Zendy; K.M. Reilly | Zendy; J. Dawes | Zendy; H. R. P. Miller | Zendy

Open Access

The Presence in Blood of Both Glycosaminoglycan and Mucosal Mast Cell Protease following Systemic Anaphylaxis in the Rat

Author(s) -

Stephen J. King,

K.M. Reilly,

J. Dawes,

H. R. P. Miller

Publication year - 1985

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000233707

Subject(s) - nippostrongylus brasiliensis , mast cell , immunology , immune system , proteases , anaphylaxis , biology , tryptase , intestinal mucosa , glycosaminoglycan , antigen , allergy , medicine , enzyme , biochemistry

The appearance in blood of rat mast cell protease II (RMCPII) and glycosaminoglycan (GAG) was examined in normal and Nippostrongylus brasiliensis-primed rats challenged intravenously with worm antigen. Systemic release of these two products occurred only in immune recipients of antigen; substantial levels of RMCPII were also present in the intestinal perfusates of these same rats and there was depletion of both RMCPII and mucosal mast cells (MMC) from the intestinal mucosa. Depletion of MMC was evident after staining for proteoglycan or for serine esterase and the mast cell counts with both histochemical techniques were highly correlated. Taken together, the results suggest that MMC are likely to be the principal source of secreted GAG and RMCPII.

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