Pressure Overload-induced Right Ventricular Failure is Associated with Re-expression of Myocardial Tenascin-C and Elevated Plasma Tenascin-C Levels | Zendy

Marleen Hessel | Zendy; Paul Steendijk | Zendy; Brigit den Adel | Zendy; Cindy I. Schutte | Zendy; Arnoud van der Laarse | Zendy

Open Access

Pressure Overload-induced Right Ventricular Failure is Associated with Re-expression of Myocardial Tenascin-C and Elevated Plasma Tenascin-C Levels

Author(s) -

Marleen Hessel,

Paul Steendijk,

Brigit den Adel,

Cindy I. Schutte,

Arnoud van der Laarse

Publication year - 2009

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000233246

Subject(s) - pressure overload , tenascin c , medicine , cardiology , heart failure , tenascin , endocrinology , microbiology and biotechnology , biology , extracellular matrix , immunohistochemistry , cardiac hypertrophy , fibronectin

We investigated whether (1) monocrotaline(MCT)-induced right ventricular (RV) dilatation is associated with re-expression of myocardial tenascin-C (TNC), (2) elevated plasma TNC levels can be used as a marker of ventricular dilatation, and (3) MCT-induced RV dilatation is associated with alterations of other remodeling-related proteins.

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