Regulation of Stem Cell Pluripotency and Neural Differentiation by Lysophospholipids | Zendy

Stuart M. Pitson | Zendy; Alice P eacute bay | Zendy

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Regulation of Stem Cell Pluripotency and Neural Differentiation by Lysophospholipids

Author(s) -

Stuart M. Pitson,

Alice P eacute bay

Publication year - 2009

Publication title -

neurosignals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.755

H-Index - 67

eISSN - 1424-8638

pISSN - 1424-862X

DOI - 10.1159/000231891

Subject(s) - lysophosphatidic acid , microbiology and biotechnology , sphingosine 1 phosphate , neural stem cell , biology , sphingosine , g protein coupled receptor , stem cell , embryonic stem cell , cellular differentiation , receptor , signal transduction , biochemistry , gene

Lysophospholipids are bioactive signalling molecules able to act through the binding of their specific G-protein-coupled receptors to exert pleiotropic effects on a wide range of cells. The most widely studied signalling lysophospholipids are lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P). LPA and S1P have been identified to have widespread developmental, physiological and pathological actions in the central nervous system and more recently have been shown to induce biological effects on various stem cell types. This review aims to summarise the current knowledge on LPA and S1P regulation of embryonic and neural stem cell biology.

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