Induction of Tolerance During the Primary Response to Simple Chemicals | Zendy

Joachim Frey | Zendy; A.L. de Weck | Zendy; H. Geleick | Zendy; L. Polák | Zendy

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Induction of Tolerance During the Primary Response to Simple Chemicals

Author(s) -

Joachim Frey,

A.L. de Weck,

H. Geleick,

L. Polák

Publication year - 1971

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000230507

Subject(s) - immunology , primary (astronomy) , inflammatory response , simple (philosophy) , medicine , biology , inflammation , philosophy , physics , epistemology , astronomy

The contact hypersensitivity and the production of antidinitro-phenyl antibodies induced in guinea pigs by epicutaneous application of dinitrochlorobenzene (DNCB) can be inhibited when dinitro-benzolsulfonate is injected i.v. during the primary response, i.e. 6 to 24 h after the topical application of DNCB. The tolerance so obtained is specific and remains for 2 to 3 months, but can be broken in some of the animals by a renewed contact with DNCB.

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