A Powerful Two-Stage Association Test Using Case-Control and Case-Parents Genotype Data | Zendy

K. F. Cheng | Zendy; W.J. Lin | Zendy; J. H. Chen | Zendy; JorngTzong Horng | Zendy

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A Powerful Two-Stage Association Test Using Case-Control and Case-Parents Genotype Data

Author(s) -

K. F. Cheng,

W.J. Lin,

J. H. Chen,

JorngTzong Horng

Publication year - 2009

Publication title -

human heredity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.423

H-Index - 62

eISSN - 1423-0062

pISSN - 0001-5652

DOI - 10.1159/000228925

Subject(s) - genotype , genetics , association (psychology) , biology , genetic association , test (biology) , stage (stratigraphy) , single nucleotide polymorphism , psychology , gene , psychotherapist , paleontology

The performance of association tests based on case-control or case-parents substudy alone can be improved by jointly using genetic data from two substudies. However, genetic data from different sources may not be combinable due to population stratification. We propose a two-stage association test based on using combinability tests in stage 1 and association tests in stage 2.

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