Comparison of Different Haplotype-Based Haplotype-Based Association Methods for Gene-Environment (G×E) Interactions in Case-Control Studies when Haplotype-Phase Is Ambiguous | Zendy

Rebecca Hein | Zendy; Lars Beckmann | Zendy; Jenny ChangClaude | Zendy

Open Access

Comparison of Different Haplotype-Based Haplotype-Based Association Methods for Gene-Environment (G×E) Interactions in Case-Control Studies when Haplotype-Phase Is Ambiguous

Author(s) -

Rebecca Hein,

Lars Beckmann,

Jenny ChangClaude

Publication year - 2009

Publication title -

human heredity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.423

H-Index - 62

eISSN - 1423-0062

pISSN - 0001-5652

DOI - 10.1159/000228923

Subject(s) - haplotype , linkage disequilibrium , logistic regression , retrospective cohort study , genetics , biology , statistics , computer science , allele , mathematics , medicine , gene

We compared four haplotype-based approaches for the analysis of gene-environment interactions when haplotype-phase is ambiguous. The methods employ different versions of the expectation maximization algorithm and differ in the choice of the reference group and in the way the risk of disease is modeled (retrospective versus prospective). Furthermore, the methods are based on distinct assumptions (such as Hardy Weinberg equilibrium). The haplotype-based methods were also compared to single-marker logistic regression (LR).

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