A New Strategy for Linkage Analysis under Epistasis Taking into Account Genetic Heterogeneity | Zendy

Alexandre Bureau | Zendy; Chantal Mérette | Zendy; Jordie Croteau | Zendy; Alain Fournier | Zendy; MarieChristine Chag | Zendy; MarcAndré Roy | Zendy; Michel Maziade | Zendy

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A New Strategy for Linkage Analysis under Epistasis Taking into Account Genetic Heterogeneity

Author(s) -

Alexandre Bureau,

Chantal Mérette,

Jordie Croteau,

Alain Fournier,

MarieChristine Chag,

MarcAndré Roy,

Michel Maziade

Publication year - 2009

Publication title -

human heredity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.423

H-Index - 62

eISSN - 1423-0062

pISSN - 0001-5652

DOI - 10.1159/000228921

Subject(s) - epistasis , locus (genetics) , genetics , biology , genetic linkage , genetic heterogeneity , locus heterogeneity , pedigree chart , quantitative trait locus , gene , computational biology , evolutionary biology , phenotype

Epistasis, the biological interaction of multiple genes modulating their individual effects, is likely omnipresent in complex diseases, and modelling epistasis in linkage studies can help detect loci with little marginal effect and detect epistatic effects themselves. We propose a complete three-step strategy for parametric linkage analysis under epistasis and heterogeneity in extended pedigrees.

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