HLA Genotyping and Antibody Characterization using the LuminexTM Multiplex Technology | Zendy

Falko M. Heinemann | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

HLA Genotyping and Antibody Characterization using the Luminex<sup>TM</sup> Multiplex Technology

Author(s) -

Falko M. Heinemann

Publication year - 2009

Publication title -

transfusion medicine and hemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 39

eISSN - 1660-3818

pISSN - 1660-3796

DOI - 10.1159/000228834

Subject(s) - human leukocyte antigen , multiplex , genotyping , typing , oligonucleotide , antibody , histocompatibility testing , immunology , transplantation , biology , antigen , medicine , computational biology , virology , genotype , dna , genetics , gene , surgery

The Luminex-based human leukocyte antigen (HLA) antibody screening technology is widespread used in laboratories affiliated to kidney transplantation programs and enables both screening (i.e. the definition of positive or negative antibody status) and antibody identification with high sensitivity and specificity. HLA typing at different levels of resolution with Luminex technology uses sequence-specific oligonucleotide probes bound to color-coded microbeads in order to identify HLA alleles encoded by the DNA sample. In general, the Luminex technology for histocompatibility analyses provides rapid sample processing in a 96-well format combined with limited technical complexity which means high cost efficiency.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research