Aldosterone Induces Apoptosis in Rat Podocytes: Role of PI3-K/Akt and p38MAPK Signaling Pathways | Zendy

Cheng Chen | Zendy; Wei Liang | Zendy; Junya Jia | Zendy; Harry van Goor | Zendy; Pravin C. Singhal | Zendy; Guohua Ding | Zendy

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Aldosterone Induces Apoptosis in Rat Podocytes: Role of PI3-K/Akt and p38MAPK Signaling Pathways

Author(s) -

Cheng Chen,

Wei Liang,

Junya Jia,

Harry van Goor,

Pravin C. Singhal,

Guohua Ding

Publication year - 2009

Publication title -

nephron experimental nephrology

Language(s) - English

Resource type - Journals

ISSN - 1660-2129

DOI - 10.1159/000228080

Subject(s) - wortmannin , podocyte , protein kinase b , apoptosis , endocrinology , medicine , pi3k/akt/mtor pathway , signal transduction , kinase , chemistry , microbiology and biotechnology , biology , kidney , biochemistry , proteinuria

Podocytes play a critical role in the pathogenesis of glomerulosclerosis. Increasing evidence suggests that aldosterone (ALD) is involved in the initiation and progression of glomerular damage. It is, however, unknown whether there is a direct injurious effect of ALD on podocytes. Therefore, in the present study, we evaluated the effect of ALD on podocyte apoptosis and studied the role of phosphatidylinositol 3-kinase/Akt (PI3-K/Akt) and p38 mitogen-activated protein kinase (p38MAPK) signaling pathways in this process.

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