White Matter Lesions and Brain Atrophy: More than Shared Risk Factors? A Systematic Review | Zendy

Auke P.A. Appelman | Zendy; Lieza G. Exalto | Zendy; Yolanda van der Graaf | Zendy; Geert Jan Biessels | Zendy; W.P.T.M. Mali | Zendy; Mirjam I. Geerlings | Zendy

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White Matter Lesions and Brain Atrophy: More than Shared Risk Factors? A Systematic Review

Author(s) -

Auke P.A. Appelman,

Lieza G. Exalto,

Yolanda van der Graaf,

Geert Jan Biessels,

W.P.T.M. Mali,

Mirjam I. Geerlings

Publication year - 2009

Publication title -

cerebrovascular diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.221

H-Index - 104

eISSN - 1421-9786

pISSN - 1015-9770

DOI - 10.1159/000226774

Subject(s) - atrophy , medicine , hyperintensity , population , white matter , pathology , magnetic resonance imaging , radiology , environmental health

White matter lesions (WML) and brain atrophy are often found on MRI in the elderly. Shared vascular risk factors may be an explanation for their concomitance. However, disturbances of white matter integrity could also be involved in the pathogenesis of brain atrophy. Our objective was to systematically review studies that investigated the relation between WML and brain atrophy on MRI, and to investigate whether there is sufficient evidence to indicate that this relation is independent of shared risk factors.

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