Adjusting Flow-Mediated Dilation for Shear Stress Stimulus Allows Demonstration of Endothelial Dysfunction in a Population with Moderate Cardiovascular Risk | Zendy

Jaume Padilla | Zendy; Blair D. Johnson | Zendy; Sean C. Newcomer | Zendy; Daniel P. Wilhite | Zendy; Timothy D. Mickleborough | Zendy; Alyce D. Fly | Zendy; Kieren J. Mather | Zendy; Janet P. Wallace | Zendy

Open Access

Adjusting Flow-Mediated Dilation for Shear Stress Stimulus Allows Demonstration of Endothelial Dysfunction in a Population with Moderate Cardiovascular Risk

Author(s) -

Jaume Padilla,

Blair D. Johnson,

Sean C. Newcomer,

Daniel P. Wilhite,

Timothy D. Mickleborough,

Alyce D. Fly,

Kieren J. Mather,

Janet P. Wallace

Publication year - 2009

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000226227

Subject(s) - brachial artery , medicine , reactive hyperemia , shear stress , population , cardiology , forearm , endothelial dysfunction , occlusion , blood flow , anatomy , blood pressure , materials science , environmental health , composite material

Although normalization of brachial artery flow-mediated dilation (FMD) to individual shear stress (FMD:shear stress ratio) has been proposed to improve this measure of endothelial function, the clinical utility of FMD normalization has not yet been demonstrated. We tested (1) whether following conventional 5-min forearm occlusion, the FMD:shear stress ratio would discriminate a population with moderate cardiovascular risk (MR) from a low-risk (LR) population, and (2) whether the dose-response profile relating shear stress to FMD would be different between the 2 populations.

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