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Evaluation of Polymorphisms in Paraoxonase 2 <i>(PON2)</i> Gene and Their Association with Cardiovascular-Renal Disease Risk in Mexican Americans
Author(s) -
Farook Thameem,
Xin He,
V. Saroja Voruganti,
Subrata Deb Nath,
Paolo Fanti,
John Blangero,
Jean W. MacCluer,
Anthony G. Comuzzie,
Nedal H. Arar,
Hanna E. Abboud
Publication year - 2009
Publication title -
kidney and blood pressure research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.806
H-Index - 51
eISSN - 1423-0143
pISSN - 1420-4096
DOI - 10.1159/000225943
Subject(s) - genotype , disease , blood pressure , subclinical infection , genetics , biology , medicine , genetic association , quantitative trait locus , gene , single nucleotide polymorphism
Genetic polymorphisms in the paraoxonase 2 (PON2) gene are thought to alter its activity and contribute to the development of cardiovascular and renal disease risk. The purpose of this study is to determine whether the Arg148Gly, Cys311Ser and rs12794795 polymorphisms of PON2 examined previously by others, are associated with type 2 diabetes (T2DM), and subclinical measures of cardiovascular and renal disease risk in Mexican Americans.

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