Virological and Biochemical Features in Elderly HCV Patients with Hepatocellular Carcinoma: Amino Acid Substitutions in HCV Core Region as Predictor of Mortality after First Treatment | Zendy

Suguru Ogura | Zendy; Norio Akuta | Zendy; Miharu Hirakawa | Zendy; Yusuke Kawamura | Zendy; Hiromi Yatsuji | Zendy; Hitomi Sezaki | Zendy; Tetsuya Hosaka | Zendy; Masahiro Kobayashi | Zendy; Fumitaka Suzuki | Zendy; Yoshiyuki Suzuki | Zendy; Mariko Kobayashi | Zendy; Satoshi Saitoh | Zendy; Yasuji Arase | Zendy; Kenji Ikeda | Zendy; Hiromitsu Kumada | Zendy

Open Access

Virological and Biochemical Features in Elderly HCV Patients with Hepatocellular Carcinoma: Amino Acid Substitutions in HCV Core Region as Predictor of Mortality after First Treatment

Author(s) -

Suguru Ogura,

Norio Akuta,

Miharu Hirakawa,

Yusuke Kawamura,

Hiromi Yatsuji,

Hitomi Sezaki,

Tetsuya Hosaka,

Masahiro Kobayashi,

Fumitaka Suzuki,

Yoshiyuki Suzuki,

Mariko Kobayashi,

Satoshi Saitoh,

Yasuji Arase,

Kenji Ikeda,

Hiromitsu Kumada

Publication year - 2009

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000225193

Subject(s) - hepatocellular carcinoma , medicine , univariate analysis , ribavirin , gastroenterology , hepatitis c virus , liver function , hepatitis c , multivariate analysis , immunology , virus

We showed previously that amino acid (aa) substitutions in HCV genotype 1b (HCV-1b) core region are negative predictors of virological response to peginterferon + ribavirin therapy, and also risk factors of hepatocarcinogenesis. The aim of this study was to evaluate the impact of core aa substitutions on mortality in elderly patients.

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