Effects of Neonatal Stress and Morphine on Kappa Opioid Receptor Signaling | Zendy

Thuy N. Vien | Zendy; Christine A. Gleason | Zendy; Sarah L. Hays | Zendy; Ronald J. McPherson | Zendy; Charles Chavkin | Zendy; Sandra E. Juul | Zendy

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Effects of Neonatal Stress and Morphine on Kappa Opioid Receptor Signaling

Author(s) -

Thuy N. Vien,

Christine A. Gleason,

Sarah L. Hays,

Ronald J. McPherson,

Charles Chavkin,

Sandra E. Juul

Publication year - 2009

Publication title -

neonatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.399

H-Index - 84

eISSN - 1661-7819

pISSN - 1661-7800

DOI - 10.1159/000220763

Subject(s) - dynorphin , morphine , κ opioid receptor , gliosis , opioid , medicine , endocrinology , hippocampal formation , receptor , pharmacology , opioid peptide , pathology

Critically ill neonates experience multiple stressors during hospitalization. Opioids are commonly prescribed to ameliorate their pain and stress. However, the enduring effects of stress and opioids are not understood. The kappa opioid system is important in the mediation of stress in adults, but little is known about its function in neonates.

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