A Natural Tetrahydropyrimidine Protects Small Bowel from Cold Ischemia and Subsequent Warm in vitro Reperfusion Injury | Zendy

Lai Wei | Zendy; Annika Wedeking | Zendy; Reinhard Büttner | Zendy; Jörg C. Kalff | Zendy; René H. Tolba | Zendy; Gerhild van EchtenDeckert | Zendy

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A Natural Tetrahydropyrimidine Protects Small Bowel from Cold Ischemia and Subsequent Warm in vitro Reperfusion Injury

Author(s) -

Lai Wei,

Annika Wedeking,

Reinhard Büttner,

Jörg C. Kalff,

René H. Tolba,

Gerhild van EchtenDeckert

Publication year - 2009

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000218338

Subject(s) - ischemia , reperfusion injury , in vitro , apoptosis , pharmacology , cold storage , transplantation , ceramide , chemistry , pathology , medicine , biochemistry , biology , horticulture

Ischemia/reperfusion (I/R) injury is a major difficulty in small bowel transplantation. Many postoperative complications are caused by damage to the intestinal mucosa following organ retrieval and during cold storage. Here we investigate whether 1-, 4-, 5-, 6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid (THP) can protect ileal mucosa and muscularis against cold ischemia and subsequent warm in vitro reperfusion injury.

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