Contrasting Effects of Glycerol and Urea Transport on Rat Pancreatic &beta;-Cell Function | Zendy

Leonard Best | Zendy; Peter de Nully Brown | Zendy; Allen P. Yates | Zendy; Jason Perret | Zendy; Myrna Virreira | Zendy; Renaud Beauwens | Zendy; Willy Malaisse | Zendy; Abdullah Sener | Zendy; Christine Delporte | Zendy

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Contrasting Effects of Glycerol and Urea Transport on Rat Pancreatic β-Cell Function

Author(s) -

Leonard Best,

Peter de Nully Brown,

Allen P. Yates,

Jason Perret,

Myrna Virreira,

Renaud Beauwens,

Willy Malaisse,

Abdullah Sener,

Christine Delporte

Publication year - 2009

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000218172

Subject(s) - aquaporin , glycerol , intracellular , urea , chemistry , biophysics , beta cell , osmolyte , depolarization , biochemistry , insulin , islet , endocrinology , biology

Pancreatic beta-cell function is influenced by changes in cell volume. Such volume changes depend on water permeability of the plasma membrane, conferred in part by aquaporins. Islet cells express aquaporin 7 (AQP7), which is permeable to urea and glycerol in addition to water. We therefore investigated the effects of glycerol and urea on rat pancreatic beta-cell function.

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