Genetic Analysis of Age-at-Onset for Cardiovascular Risk Factors in a Brazilian Family Study | Zendy

Suely Ruiz Giolo | Zendy; Alexandre C. Pereira | Zendy; Mariza de Andrade | Zendy; Camila Maciel de Oliveira | Zendy; José Eduardo Krieger | Zendy; Júlia Maria Pavan Soler | Zendy

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Genetic Analysis of Age-at-Onset for Cardiovascular Risk Factors in a Brazilian Family Study

Author(s) -

Suely Ruiz Giolo,

Alexandre C. Pereira,

Mariza de Andrade,

Camila Maciel de Oliveira,

José Eduardo Krieger,

Júlia Maria Pavan Soler

Publication year - 2009

Publication title -

human heredity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.423

H-Index - 62

eISSN - 1423-0062

pISSN - 0001-5652

DOI - 10.1159/000218111

Subject(s) - diabetes mellitus , demography , covariate , family history , medicine , age of onset , proportional hazards model , trait , polygenic risk score , quantitative trait locus , population , random effects model , biology , environmental health , genetics , meta analysis , endocrinology , gene , statistics , disease , genotype , mathematics , sociology , computer science , single nucleotide polymorphism , programming language

Statistical analysis of age-at-onset involving family data is particularly complicated because there is a correlation pattern that needs to be modeled and also because there are measurements that are censored. In this paper, our main purpose was to evaluate the effect of genetic and shared family environmental factors on age-at-onset of three cardiovascular risk factors: hypertension, diabetes and high cholesterol.

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