The Impact of Heat Shock Protein 70 Gene Variations on Clinical Presentation and Outcome in Schizophrenic Inpatients | Zendy

ChiUn Pae | Zendy; Antonio Drago | Zendy; Jung-Jin Kim | Zendy; Laura Mandelli | Zendy; Diana De Ronchi | Zendy; Alessandro Serretti | Zendy

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The Impact of Heat Shock Protein 70 Gene Variations on Clinical Presentation and Outcome in Schizophrenic Inpatients

Author(s) -

ChiUn Pae,

Antonio Drago,

Jung-Jin Kim,

Laura Mandelli,

Diana De Ronchi,

Alessandro Serretti

Publication year - 2009

Publication title -

neuropsychobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.71

H-Index - 83

eISSN - 1423-0224

pISSN - 0302-282X

DOI - 10.1159/000218075

Subject(s) - heat shock protein , haplotype , positive and negative syndrome scale , medicine , single nucleotide polymorphism , schizophrenia (object oriented programming) , gene , psychosis , biology , genetics , genotype , psychiatry

We previously investigated a group of single-nucleotide polymorphisms of a set of genes coding for heat shock proteins (HSPA1A, HSPA1B and HSPA1L) and found a significant association between one HSPA1B variation and schizophrenia (SZ). We now report an association between a set of variations (rs2227956, rs2075799, rs1043618, rs562047 and rs539689) within the same genes and a larger sample of schizophrenic inpatients. A single variation, rs539689 (HSPA1B), was found to be marginally associated with Positive and Negative Syndrome Scale (PANSS) positive scores at discharge, and haplotype analysis revealed a significant association between improvement in PANSS scores with both A-C-G-G and A-C-G-G haplotypes. These findings further support a role of heat shock proteins in the pathophysiology of SZ.

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