CD4+ T Cells and Immunosenescence – A Mini-Review | Zendy

Alexander C. Maue | Zendy; Laura Haynes | Zendy

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CD4+ T Cells and Immunosenescence – A Mini-Review

Author(s) -

Alexander C. Maue,

Laura Haynes

Publication year - 2009

Publication title -

gerontology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.397

H-Index - 94

eISSN - 1423-0003

pISSN - 0304-324X

DOI - 10.1159/000214842

Subject(s) - immunosenescence , immune system , immunity , immunology , t cell , vaccination , compartment (ship) , biology , t lymphocyte , function (biology) , microbiology and biotechnology , oceanography , geology

Age-related declines in immune function are associated with reduced humoral responses following vaccination or infection. Central to this defect is a decline in naïve CD4+ T cell function. In this review, we discuss factors intrinsic and extrinsic to the CD4+ T cell compartment that affect host immunity and propose means by which deficient CD4+ T cell function can be fully restored in the aged.

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