Effects of Corticosteroids on Osteopontin Expression in a Murine Model of Allergic Asthma | Zendy

Masatsugu Kurokawa | Zendy; Satoshi Konno | Zendy; Satoshi Matsukura | Zendy; Mio Kawaguchi | Zendy; Koushi Ieki | Zendy; Shintarou Suzuki | Zendy; Miho Odaka | Zendy; Shin Watanabe | Zendy; Tetsuya Homma | Zendy; Masayuki Sato | Zendy; Hiroko Takeuchi | Zendy; Takashi Hirose | Zendy; Shau-Ku Huang | Zendy; Mitsuru Adachi | Zendy

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Effects of Corticosteroids on Osteopontin Expression in a Murine Model of Allergic Asthma

Author(s) -

Masatsugu Kurokawa,

Satoshi Konno,

Satoshi Matsukura,

Mio Kawaguchi,

Koushi Ieki,

Shintarou Suzuki,

Miho Odaka,

Shin Watanabe,

Tetsuya Homma,

Masayuki Sato,

Hiroko Takeuchi,

Takashi Hirose,

Shau-Ku Huang,

Mitsuru Adachi

Publication year - 2009

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000210647

Subject(s) - osteopontin , ovalbumin , immunology , medicine , dexamethasone , eosinophil , allergic inflammation , bronchoalveolar lavage , allergy , asthma , lung , immune system

Osteopontin (OPN) contributes to the development of T helper 1 (Th1)-mediated immunity and Th1-associated diseases. However, the role of OPN in bronchial asthma is unclear. Corticosteroids reduce airway inflammation, as reflected by the low eosinophil and T-cell counts, and the low level of cytokine expression. We investigated OPN production and the inhibitory effects of corticosteroids on OPN production in a murine model of allergic asthma.

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