Evaluation of Potential Power Gain with Imputed Genotypes in Genome-Wide Association Studies | Zendy

Tim Becker | Zendy; Antònia Flaquer | Zendy; Felix F. Brockschmidt | Zendy; Christine Herold | Zendy; Michael Steffens | Zendy

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Evaluation of Potential Power Gain with Imputed Genotypes in Genome-Wide Association Studies

Author(s) -

Tim Becker,

Antònia Flaquer,

Felix F. Brockschmidt,

Christine Herold,

Michael Steffens

Publication year - 2009

Publication title -

human heredity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.423

H-Index - 62

eISSN - 1423-0062

pISSN - 0001-5652

DOI - 10.1159/000210446

Subject(s) - international hapmap project , imputation (statistics) , single nucleotide polymorphism , sample size determination , genotype , statistical power , context (archaeology) , genetic association , snp , genome wide association study , computational biology , genetics , biology , 1000 genomes project , statistics , computer science , mathematics , gene , missing data , paleontology

With the beginning of the era of genome-wide association studies methods to obtain 'in silico' genotypes have gained importance. In this context, an evaluation of genome-wide power levels of current marker panels and the power gain achievable with imputed genotypes are of high interest.

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