Ironing Out the Wrinkles in Host Defense: Interactions between Iron Homeostasis and Innate Immunity | Zendy

Lijian Wang | Zendy; Bobby J. Cherayil | Zendy

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Ironing Out the Wrinkles in Host Defense: Interactions between Iron Homeostasis and Innate Immunity

Author(s) -

Lijian Wang,

Bobby J. Cherayil

Publication year - 2009

Publication title -

journal of innate immunity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.078

H-Index - 64

eISSN - 1662-8128

pISSN - 1662-811X

DOI - 10.1159/000210016

Subject(s) - innate immune system , iron homeostasis , immunity , biology , virulence , homeostasis , immune system , micronutrient , pathogen , immunology , host (biology) , microbiology and biotechnology , metabolism , chemistry , ecology , biochemistry , gene , organic chemistry

Iron is an essential micronutrient for both microbial pathogens and their mammalian hosts. Changes in iron availability and distribution have significant effects on pathogen virulence and on the immune response to infection. Recent advances in our understanding of the molecular regulation of iron metabolism have shed new light on how alterations in iron homeostasis both contribute to and influence innate immunity. In this article, we review what is currently known about the role of iron in the response to infection.

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